| Effects of Atorvastatin on Warfarin-induced Aortic Medial Calcification and Systolic Blood Pressure in Rats |
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| 引用本文： | 刘承云,万晶晶,杨群芳,戚本玲,彭雯,陈学林. Effects of Atorvastatin on Warfarin-induced Aortic Medial Calcification and Systolic Blood Pressure in Rats[J]. 华中科技大学学报(医学英德文版), 2008, 28(5): 535-538. DOI: 10.1007/s11596-008-0510-1 |
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| 作者姓名： | 刘承云 万晶晶 杨群芳 戚本玲 彭雯 陈学林 |
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| 作者单位： | Department of Geriatrics，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Centre of Hyperbaric Oxygen，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology |
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| 摘 要： | The effect of atorvastatin on warfarin-induced aortic medial calcification and systolic blood pressure （SBP） of rats induced by warfarin was studied. Thirty healthy and adult rats were randomly divided into Warfarin group （n=10）, Atorvastatin group （n=10） and normal control group （n=10）. Caudal arterial pressure of rats was measured once a week, and 4 weeks later, aorta was obtained. Elastic fiber, collagen fiber and calcium accumulation in tunica media of cells were measured by Von Kossa staining. The results showed that warfarin treatment led to elevation of systolic blood pressure and aortic medial calcification. The chronic treatment also increased collagen, but decreased elastin in the aorta. However, the atorvastatin treatment had adverse effects. It was concluded that treatment with atorvastatin presented evidence of blood pressure lowing and calcification reducing. These data demonstrate that atorvastatin protected aortic media from warfarin-induced calcification and elevation of systolic blood pressure.
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| 关 键 词： | 阿托伐他汀 收缩压 主动脉 钙化 杀鼠灵 长期治疗 动脉中层 成年大鼠 |
Effects of atorvastatin on warfarin-induced aortic medial calcification and systolic blood pressure in rats |
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| Chengyun Liu,Jingjing Wan,Qunfang Yang,Benling Qi,Wen Peng,Xuelin Chen. Effects of atorvastatin on warfarin-induced aortic medial calcification and systolic blood pressure in rats[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2008, 28(5): 535-538. DOI: 10.1007/s11596-008-0510-1 |
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| Authors: | Chengyun Liu Jingjing Wan Qunfang Yang Benling Qi Wen Peng Xuelin Chen |
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| Affiliation: | 1. Department of Geriatrics, Wuhan 430022, China
2. Centre of Hyperbaric Oxygen, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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| Abstract: | The effect of atorvastatin on warfarin-induced aortic medial calcification and systolic blood pressure (SBP) of rats induced by warfarin was studied. Thirty healthy and adult rats were randomly divided into Warfarin group (n=10), Atorvastatin group (n=10) and normal control group (n=10). Caudal arterial pressure of rats was measured once a week, and 4 weeks later, aorta was obtained. Elastic fiber, collagen fiber and calcium accumulation in tunica media of cells were measured by Von Kossa staining. The results showed that warfarin treatment led to elevation of systolic blood pressure and aortic medial calcification. The chronic treatment also increased collagen, but decreased elastin in the aorta. However, the atorvastatin treatment had adverse effects. It was concluded that treatment with atorvastatin presented evidence of blood pressure lowing and calcification reducing. These data demonstrate that atorvastatin protected aortic media from warfarin-induced calcification and elevation of systolic blood pressure. |
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| Keywords: | atorvastatin systolic blood pressure calcification/aortic |
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