食管鳞癌MMP-2和CD44v6表达与侵袭、转移及预后之间的关系

Expression of CD44v6 and MMP-2 in esophagus squamous cell carcinoma and their association with invasion, metastasis and prognosis

AIM: To detect the expression of CD44v6 and MMP-2 in esophagus squamous cell carcinoma, and to explore their association with invasion, metastasis and prognosis. METHODS: A rapid immunohistochemical method (streptoavidin-peroxidase,SP) was used to detect CD44v6 and MMP-2 protein in 43 cases of esophagus squamous cell carcinoma-treated without radiotherapy or chemotherapy before operation. RESULTS: The expression rates of CD44v6 and MMP-2 in esophagus squamous cell carcinoma were 62.7% (27/43) and 65.1% (28/43), respectively. The positive expression of MMP-2 and CD44v6 were significantly correlated with lymph node metastasis, TNM stage and postoperative hematogenous metastasis (P<0.05). The 3-and 5-year survival rates of CD44v6 positive patients were 25.62% and 6.41%. The 3-and 5-year survival rates of CD44v6 negative patients were 64.71% and 56.82%. There was significant difference for survival time between CD44v6 positive and CD44v6 negative patients (P=0.000). The 3-and 5-year survival rates of MMP-2 positive patients were 18.8% and 8.60%. The 3-and 5-year survival rates of MMP-2 negative patients were 66.30% and 42.82%. There was significant difference between MMP-2 positive and MMP-2 negative groups (P = 0.0067). CD44v6 positive expression was significantly correlated with MMP-2 positive expression (P= 0.007). CONCLUSION: CD44v6 and MMP-2 may play a role in esophagus squamous cell carcinoma invasion, lympha node metastasis, and postoperative hematogenous metastasis as well as the prognosis of the patients.