犬逆行灌注心不停跳心脏手术中血浆心钠素变化

目的 :探讨经冠状静脉窦逆行灌注心脏不停跳方法对体外循环术中心肌保护的效果。方法 :16只健康杂种犬随机分为实验组 (浅低温逆行灌注心不停跳组 )与对照组 (中度低温心停跳组 ) ,每组 8只。体外循环 (CPB) 15 0分钟。于 6个时点采静脉血 ,检测血浆心钠素 (ANP)。结果 :两组CPB期间ANP及CGRP与CPB前比较均有不同程度升高 ,实验组ANP较对照组升高快 ,ANP在再灌注 30分钟达峰值 ,实验组与对照组ANP在CPB中各时点均有非常显著性差异 (P <0 0 1)。结论 :ANP可作为CPB过程中检测心肌保护效果的敏感指标 ;心脏不停跳法有利于ANP的合成和释放 ,具有较佳的心肌保护效果。

The changes of atrial natriuretic peptide in retrograde heart surgery in beating heart in dogs

Objective:To study the myocardial protective effects on retrograde perfusion via coronary sinus in beating heart Methods:Sixteen health mongrel dogs were randomly divided into experimental group(with mild hypothermic retrograde perfusion via coronary sinus in beating heart n=8)and control group(on arrest heart with mild hypothermic) Cardiopulmonary bypass(CPB) was performed for 150 minutes Plasma atrial natriuretic peptide (ANP) of two groups were respeptively measured and contrasted at six different time intervals Results:ANP in two groups increased in varying degrees during CPB ANP in experimental group increased more quickly The peak of ANP appeared 30 minutes after reperfusion ANP in experimental group were significantly higher than that in control group(P<0 01) Conclusion:Plasma ANP may be sensitive detective guideline in myocardial protective effects Beating heart are propitious to the compose and release of ANP Myocardial protective effects in experimental group is superior to that in control group ;