Biphasic effect of somatostatin on oral glucose tolerance in maturity-onset diabetes |
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Authors: | W V Tamborlane R S Sherwin R Hendler P Felig |
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Institution: | 1. Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn.USA;2. Department of Pediatrics, Yale University School of Medicine, New Haven, Conn.USA |
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Abstract: | Oral glucose tolerance was examined in five maturity-onset diabetics during the infusion of somatostatin or saline. Somatostatin inhibited glucose-stimulated insulin release and reduced plasma glucagon by 50%--65%. The rise in plasma glucose after glucose ingestion was initially (at 30--120 min) reduced by somatostatin. However, beyond 3 hr, plasma glucose levels were 50--200 mg/100 ml higher, with somatostatin reaching concentrations at 6 hr that were twofold higher than those observed with saline ( p less than 0.005). The degree of late glucose intolerance was inversely related to postglucose plasma insulin concentrations (p less than 0.01). These findings demonstrate a biphasic effect of somatostatin on oral glucose tolerance in maturity-onset diabetes. The exaggerated later hyperglycemia is related to suppression of insulin secretion. The initial blunting of postprandial hyperglycemia may reflect decreased carbohydrate absorption and/or hypoglucagonemia-mediated enhancement of glucose disposal. |
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Keywords: | Address reprint requests to Dr Robert S Sherwin Department of Internal Medicine Yale University School of Medicine 333 Cedar Street New Haven Conn 06510 |
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