拉西地平对动脉粥样硬化新西兰兔LOX-1的影响

目的：观察拉西地平对兔颈总动脉血凝素样氧化低密度脂蛋白受体-1（LOX-1）表达的影响。方法：球囊拉伤＋高脂饮食6周建立动物模型，将30只雄性新西兰白兔随机分成五组：Control组、M0del组、Laci—L组、Laci—H组和Atovas组。6周后检测血脂水平。计算左侧颈总动脉新生内膜面积（SI）与中膜面积（SM）之比（SI／SM），病理形态学观察颈总动脉组织学变化，逆转录-聚合酶链反应（RT—PCR）和免疫组化分别检测颈总动脉血管壁LOX-lmRNA和蛋白的表达。结果：左侧颈总动脉球囊拉伤＋高脂饮食成功建立了兔动脉粥样硬化模型，在Model组中，血中总胆固醇（TC）、低密度脂蛋白（LDL-c）水平明显升高；SI／SM比值明显增大，颈总动脉血管壁LOX-lmRNA与蛋白水平表达增强；Laci—L组和Laci—H组血脂无明显降低，但是，SI／SM、LOX-lmRNA和蛋白水平较Model组显著降低（P〈0．01）。结论：拉西地平减少内膜LOX-1表达是其抗动脉粥样硬化作用机制之一。

COMMUNITY HOSPITAL OBSERVATION OF TREATMENT OF 56 CASES OF SYPHILIS IN PREGNANCY

Objective：To explore the community hospitals of patients with syphilis during pregnancy protection advantages. Meth- ods： 56 cases of Syphilis serology diagnosed as gestational patients, including 45 cases of which were treated with benzathine penicillin therapy,the treatment based on the duratien of pregnancy is divided into four groups , pregnancy 0 - 12w treatment group （A group n = 22 ） ; B： second trimester 13-28w treatment group （B group , n = 14 ） , and third trimester of pregnancy 29 -40w treatment group （ C group , n = 9） and untreated （ D group n = 11 ）. Results： The treatment group in term labor , premature rupture of mem- branes , birth defects and stillbirths abortion compared with no treatment group difference was statistically significant （ P 〈 0. 05 or P 〈 0. 01）. Four groups of patients with neonatal treatment group has got the normal newborn successful rate of 81.8% , the perinatal mor- tality rate was only 4.5% congenital syphilis to 18.2% ; non - treatment group childbirth normal newborn rate of 27.3% , Perinatal mortality rate of 54.5% , and 72.7% of congenital syphilis , the two groups compare X2 = 19.33 , P 〈0.001 ,first trimester , second trimester treatment group compared with the third trimester treatment group and the non - treatment group perinatal prognosis is good. Conclusion：The full use of community hospitals convenience advantages of infectious disease prevention , diagnosis and treatment , strengthen syphilis screening in pregnancy management and anti - syphilis treatment during pregnancy, effectively reduces the adverse pregnancy outcomes of pregnancy syphilis .