|
|||||
|
|
| SARS病毒抗体第一代参考品的研制及初步应用 | |
| 引用本文： | 王佑春,李秀华,貌盼勇,毕胜利,许文波,宋爱京.SARS病毒抗体第一代参考品的研制及初步应用[J].中华微生物学和免疫学杂志,2003,23(10):822-825. |
| 作者姓名： | 王佑春 李秀华 貌盼勇 毕胜利 许文波 宋爱京 |
| 作者单位： | 1. 中国药品生物制品检定所细胞室 2. 解放军302医院病毒研究室 3. 中国疾病控制中心病毒所 |
| 摘 要： | 目的 建立严重急性呼吸综合征(SARS)病毒抗体参考品，用于对SARS病毒抗体诊断试剂的实验室评价。方法 收集临床确诊为SARS病人血清和非SARS人群血清，用不同的SARS病毒抗体诊断试剂进行检测筛查，选择不同样品组成参考品。并用该参考品对不同试剂进行初步评价。结果 SARS病毒ISM抗体的参考品由38份组成，其中包括11份阳性参考品、20份阴性参考品、灵敏度样品6份，精密性样品1份；SARS病毒总抗体(包括IgG)由46份组成，其中包括18份阳性参考品、20份阴性参考品、灵敏度样品7份，精密性样品1份。结论 初步应用结果显示该参考品确实能够反应不同试剂的质量差异。 |
| 关 键 词： | SARS病毒 抗体 第一代参考品 严重急性呼吸综合征 传染性非典型肺炎 |
| 修稿时间： | 2003年6月16日 |
The study and primary application of anti-SARS virus antibody reference panels |
|
| WANG You-chun ,LI Xiu-hua,MAO Pan-yong,BI Sheng-li,XU Wen-bo,SONG Ai-jing.The study and primary application of anti-SARS virus antibody reference panels[J].Chinese Journal of Microbiology and Immunology,2003,23(10):822-825. | |
| Authors: | WANG You-chun LI Xiu-hua MAO Pan-yong BI Sheng-li XU Wen-bo SONG Ai-jing |
| Institution: | WANG You-chun *,LI Xiu-hua,MAO Pan-yong,BI Sheng-li,XU Wen-bo,SONG Ai-jing. *Department of Cell Biology,National Institute for the Control of Pharmaceutical and Biological Products,Beijing 100050,China |
| Abstract: | Objective To establish reference panels of anti-SARS virus antibody for assessment of the quality of SARS virus antibody diagnostic kits. Methods Sera were collected from patients with clinically diagnosed SARS and non-SARS population. All sera were tested with different diagnostic assays and different sera were selected as candidate panels. Results The SARS virus IgM antibody panel is composed of 11 positive sera, 20 negative sera, 6 diluted sera for sensitivity and 1 sera for picion. The SARS virus total antibody (including IgG) panel is composed of 18 positive sera, 20 negative sera, 7 diluted sera for sensitivity and 1 sera for picion. Conclusion The primary application of these panels indicated that these panels can identify the quality of SARS antibody kits from different manufactures. |
| Keywords: | Severe acute respiratory syndrome Virus Antibody Reference panel |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |