机理性灭活体外细胞色素P450及其对体内药物相互作用定量预测的研究进展

近10年来，以体外细胞色素P450抑制数据预测潜在临床药物相互作用的方法得到极大发展。药物相互作用（drug-drug interaction）研究一直是临床实践和新药开发中的重要环节。本文对近年来引起广泛重视的机理性灭活作用（mechanismbased inactivation）进行总结分析，综合传统和经简化的鉴定机理性灭活作用方法，并介绍预测体内由机理性灭活引起药物相互作用的模型和影响参数。

Advances in predicting of drug-drug interaction in vivo by using cytochrome P450 mechanism-based inhibition data in vitro

In the last decade, the approaches for the in vitro inhibition assessment of the potentials of drug-drug interaction in vivo have received process. DDIs remain an important issue in clinical practice and the development of new drugs. Mechanism-based inactivation is gaining more attention among in vitro study. This review would describe methods in identifying mechanism-based inactivation, and introduce predictive models and parameters in the field.