川崎病并冠状动脉扩张危险因素分析

目的:探讨川崎病并发冠状动脉扩张的危险因素.方法:确诊为川崎病的患儿126例,根据超声结果分为冠状动脉扩张组和无冠状动脉扩张组,对其性别、年龄、发热天数、急性期C-反应蛋白、血沉、白蛋白、血清钠离子浓度等资料进行比较分析,并作logistic相关分析.结果:126例川崎病患儿并发冠状动脉扩张者66例(占52.38%),无扩张者60例(占47.62%).两组患儿年龄、发热天数、白蛋白、血钠(低钠)差异有显著性(P＜0.05);多因素Logistic回归分析提示年龄、发热时间、血钠浓度和冠脉扩张密切相关(P＜0.05).结论:川崎病患儿并冠状动脉扩张与患儿年龄小、发热时间长及血钠浓度低密切相关.

Analysis of risk factors for coronary artery lesions in Kawasaki disease

Objective:To investigate the risk factors for coronary artery lesions in kawasaki disease.Methods:126 children with kawasaki disease were collected.All of the children were divided into two groups according to the results of echocardiogram of coronary artery: one group was children with coronary artery lesions(CAL )and another group no coronary artery lesions(CAL-).The parameters studied were sex,age,duration of fever,C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),albumine,serum sodium levels and so on.These were examined both in univariate analysis and multiple logistic regression.Results:Among the 126 cases,the complication of coronary artery lesions was 66(52.38%).Univariate analysis indicated that age,the duration of fever,albumine and low serum sodium had significant differences between the two groups(P<0.05).Multiple logistic regression analysis indicated age,duration of fever and low serum sodium concentration had close relationship with coronary artery lesions(P<0.05).Conclusion:Age<1 year,duration of fever prior to treatment and low serum sodium are independent risk factors for coronary artery lesions.