血清C-反应蛋白和血黏度联合估计急性冠脉综合征预后的研究

目的探讨血清C-反应蛋白(CRP)及血黏度与急性冠脉综合征(ACS)预后的关系。方法CRP浓度的测定采用胶乳法。以CRP≥3.0 mg/L为预测心脏事件的临界值,将ACS患者分成ACSⅠ组(CRP≥3.0 mg/L)和ACSⅡ组(CRP<3.0 mg/L)。同时测定2组患者的血黏度。结果ACSⅠ组、ACSⅡ组CRP浓度及血浆黏度均明显高于正常对照组,ACSⅠ组心脏事件发生率明显高于ACSⅡ组。结论血清CRP水平参与了冠心病的发生,CRP≥3.0 mg/L者发生心脏事件几率高,提示在某种程度上血清CRP水平判断ACS预后较血黏度更有价值。CRP≥3.0 mg/L可作为判断国人ACS预后的界限值以便预测。

Study of the application of serum C-reactive protein and blood viscosity for predicting prognosis of acute coronary syndrome

Objective It is to explore the relationship of serum C-reactive protein(CRP) and blood viscosity with prognosis of acute coronary syndrome(ACS).Methods The content of CRP was determined with latex method.The patients with ACS were divided into ACS group I(CRP≥3.0 mg/L) and ACS group II(CRP<3.0 mg/L) according to the critical value of CRP≥3.0 mg/L for predicting heart incidence. Then blood viscosity of the two groups was measured.Results The contents of CRP and blood viscosity in ACS group I and ACS group II were both significantly higher than that in normal control group.The incidence rate of heart incidence in ACS group I was obviously higher than that in ACS group II.Conclusion The level of Serum CRP took a part in the occurrence of coronary heart disease,and the ones with CRP ≥3.0 mg/L have high probability of heart incidence.It shows that serum CRP has more value for predicting prognosis of ACS than blood viscosity.CRP ≥3.0 mg/L can be used as the critical value for diagnosing prognosis of ACS.