Heat Shock Protein-70 Expression in Vitiligo and its Relation to the Disease Activity |
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| Authors: | Reham William Doss Abdel-Aziz A El-Rifaie Amr M Abdel-Wahab Yasser M Gohary Laila A Rashed |
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| Institution: | From the Department of Dermatology, Faculty of Medicine, Beni-Suef University, Beni Suef, Egypt;1Department of Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt |
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| Abstract: | Background:Vitiligo is a progressive depigmenting disorder characterized by the loss of functional melanocytes from the epidermis. The etiopathogenesis of vitiligo is still unclear. Heat shock proteins (HSPs) are prime candidates to connect stress to the skin. HSPs were found to be implicated in autoimmune diseases such as rheumatoid arthritis and other skin disorders as psoriasis.Results:Our analysis revealed a significantly higher expression of HSP-70 mRNA in lesional skin biopsies from vitiligo patients compared to nonlesional skin biopsies from vitiligo patients (P < 0.001) and compared to skin biopsies from healthy controls (P < 0.001). The level of HSP-70 was not found to be correlated with age, sex, or disease duration. The expression of HSP-70 was correlated with the disease activity and patients with active vitiligo showed higher mean HSP-70 level compared to those with inactive disease.Conclusions:HSP-70 plays a role in the pathogenesis of vitiligo and may enhance the immune response in active disease. |
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| Keywords: | Heat shock protein-70 messenger RNA real-time polymerase chain reaction vitiligo |
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