| 超抗原SPE对SLE患者外周血T淋巴细胞增殖和凋亡作用的研究 |
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| 引用本文： | 王红兵,杨策尧,曾卫玲. 超抗原SPE对SLE患者外周血T淋巴细胞增殖和凋亡作用的研究[J]. 中国皮肤性病学杂志, 2005, 19(7): 395-397 |
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| 作者姓名： | 王红兵 杨策尧 曾卫玲 |
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| 作者单位： | 1. 昆明医学院第一附属医院皮肤科,云南,昆明,650031
2. 昆明医学院第一附属医院中心实验室,云南,昆明,650031 |
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| 基金项目： | 云南省卫生厅科学研究基金(99Q028) |
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| 摘 要： | 目的研究超抗原SPE对SLE患者外周血T淋巴细胞增殖及凋亡的作用。方法用SPE刺激SLE患者外周血T淋巴细胞,用流式细胞仪观察T淋巴细胞增殖、细胞表型以及凋亡情况,ELISA法检测IL2产生。结果SPE有促进SLE患者外周血T淋巴细胞增殖的作用,增殖细胞主要为CD4+T淋巴细胞,同时产生大量的IL2;再次用SPE刺激,可诱导T淋巴细胞凋亡。结论链球菌感染后,可能通过SPE诱导T淋巴细胞激活、随后出现细胞凋亡的途径而导致SLE病情活动加重。
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| 关 键 词： | 超抗原 红斑狼疮,系统性 T淋巴细胞 凋亡 增殖 |
| 文章编号： | 1001-7089(2005)07-0395-03 |
Study on Proliferation and Apoptosis of Superantigen SPE on T Lymphocyte in SLE Peripheral Blood |
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| WANG Hong-bing,YANG Ce-rao,ZENG Wei-ling. Study on Proliferation and Apoptosis of Superantigen SPE on T Lymphocyte in SLE Peripheral Blood[J]. The Chinese Journal of Dermatovenereology, 2005, 19(7): 395-397 |
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| Authors: | WANG Hong-bing YANG Ce-rao ZENG Wei-ling |
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| Abstract: | Objective To study the effect of proliferation and apoptosis of superantigen SPE in SLE.Methods To use SPE to stimulate T lymphocyte of SLE peripheral blood;To observe proliferation, cell phenotype and apoptosis on T lymphocyte with flow cytometry;to examine IL-2 production with ELISA.Results SPE have improved on proliferation of T lymphocyte of SLE peripheral blood,specially CD4~+ cell,and producing a large of IL-2.Again with SPE stimulation,induced T lymphocyte apoptosis.Conclusion After streptococcus infected,it induced T lymphocyte apoptosis activation through SPE and then appeared lymphocyte apoptosis to lead to aggravate the state of illness activation. |
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| Keywords: | Superantigen SLE T lymphocyte Apoptosis Proliferation |
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