| CyclinB1在非霍奇金淋巴瘤中的表达及诊断价值 |
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| 引用本文： | 谢贤和,曾慈梅,谈顺,王岩,姚红霞,陈岩菊,王琳,吴琼诗,袁小琴,邢雪花,黄海燕,陈俊民,麦泽锋,李慧艳,林银英. CyclinB1在非霍奇金淋巴瘤中的表达及诊断价值[J]. 海南医学院学报, 2011, 17(2): 155-158 |
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| 作者姓名： | 谢贤和 曾慈梅 谈顺 王岩 姚红霞 陈岩菊 王琳 吴琼诗 袁小琴 邢雪花 黄海燕 陈俊民 麦泽锋 李慧艳 林银英 |
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| 作者单位： | 1. 海南省人民医院,海南,海口,570311
2. 海口市人民医院,海南,海口,570208 |
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| 摘 要： | 目的:探讨CyclinB1在良、恶性淋巴疾病表达差异以及在恶性淋巴瘤中表达与多种预后因素的相互关系,并分析其表达的临床意义。方法:采用免疫组织化学ABC法,检测CyclinB1在83例非霍奇金淋巴瘤(NHL)组织及20例淋巴结反应性增生(RH)组织中的表达情况。结果:CyclinB1在NHL中的表达显著高于RH组织中的表达(P<0.01);NHL中CyclinB1在Ⅲ+Ⅳ期的表达显著高于Ⅰ+Ⅱ期(P<0.05),在有结外受侵的NHL患者中明显高于无结外受侵的患者(P<0.05),在侵袭性NHL显著高于惰性NHL(P<0.05)。结论:CyclinB1可能参与NHL的进展。检测CyclinB1的表达情况,有助于NHL和RH的鉴别诊断,对判断NHL的恶性程度有一定的临床价值。
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| 关 键 词： | CyclinB1 非霍奇金淋巴瘤 淋巴结反应性增生 免疫组织化学 |
The expression and diagnostic value of cyclinB1 in non-Hodgkin's lymphoma |
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| XIE Xian-he,ZENG Ci-mei,TAN Shun,WANG Yan,YAO Hong-xia,CHEN Yan-ju,WANG Lin,WU Qiong-shi,YUAN Xiao-qin,XING Xue-hua,HUANG Hai-yan,CHEN Jun-min,MAI Ze-feng,LI Hui-yan,LIN Yin-ying. The expression and diagnostic value of cyclinB1 in non-Hodgkin's lymphoma[J]. Journal of Hainan Medical College, 2011, 17(2): 155-158 |
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| Authors: | XIE Xian-he ZENG Ci-mei TAN Shun WANG Yan YAO Hong-xia CHEN Yan-ju WANG Lin WU Qiong-shi YUAN Xiao-qin XING Xue-hua HUANG Hai-yan CHEN Jun-min MAI Ze-feng LI Hui-yan LIN Yin-ying |
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| Affiliation: | 1(1.Hainan Provincial People′s Hospital,Haikou 570311;2.Haikou Municipal Hospital,Haikou 570208,China) |
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| Abstract: | Objective： To explore the difference in cyclinB1 expression between benign and malignant lymphoid disease as well as its predictive value in the prognosis of malignant lymphoma.Methods： The expression of cyclinB1 in 83 non-Hodgkin′s lymphoma（NHL） cases and 20 reactive lymphoid tissue hyperplasia（RH） cases were detected and compared with ABC immunohistochemistry.Results： The positive expression rate of cyclinB1 in NHL was significantly higher than that in RH（P〈0.01）,in aggressive NHL than those in stage Ⅰ＋ Ⅱ （P〈0.05）. Conclusion： CyclinB1 is possibly involved with NHL progression thus its expression can be helpful in differentiation between NHL and RH, as well as judging the malignancy degree of NHL. |
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| Keywords: | CyclinB1 |
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