认知疗法联合舍曲林治疗产褥期抑郁症临床观察

目的:探讨认知疗法联合舍曲林治疗产褥期抑郁症的疗效和安全性.方法:将80例产褥期抑郁症患者随机分为研究组(认知疗法+舍曲林)和对照组(舍曲林),每组40例,观察治疗8周.用汉密顿抑郁量表(HAMD)和副反应量表(TESS)分别评定临床疗效和不良反应.结果:在治疗后第4周末,研究组显效率和有效率均高于对照组(P均＜0.0...

Clinical effects of cognitive therapy combining with sertraline on postpartum depression

Objective： To observe the efficacy and safety of cognitive therapy combining with sertraline in treatment of the patients with postpartum depression.Methods： A total of 80 patients with postpartum depression were randomly assigned to study group（treated by cognitive psychological therapy combining with sertraline） and control group（treated by sertraline alone） for 8 weeks.Each had 40 cases.The Hamilton Depressive Scale（HAMD） and Treatment Emergent Side Effect Scale（TESS） were used to evaluate the efficacy and adverse effects respectively. Results： After treatment of 4 weeks, the rates of patients that showed significant efficacy and efficacy in the study group was significantly higher than those in the control group （P both 〈0.05）. After 8 weeks of treatment, the significant difference in rates of patients that showed significant efficacy remained （P〈0.05）, but the efficacy rate was not significantly different between the two groups （P〉0.05）. After treatment, the scores of HAMD significantly decreased in both groups （P both〈0.05）, but it was more obvious in the study group （P 〈0.05）. No significant difference in TESS scores was shown in neither of the two groups after treatment. Oonclusions： From the aspect of early rehabilitation, cognitive psychological therapy combining with sertraline is much more effective than sertraline alone in treatment of the patients with postpartum depression.