抗焦虑抑郁治疗对高血压患者的动态血压及心率变异性的影响

目的 探讨抗焦虑抑郁药物对伴有焦虑抑郁的高血压患者的动态血压及心率变异性（HRV）的影响.方法 80例并发焦虑抑郁的高血压患者,随机分为对照组（常规降压＋安慰剂）和试验组（常规降压＋抗焦虑抑郁剂）,并随访6周,观察两组治疗前、后动态血压及HRV变化情况.结果 抗焦虑抑郁治疗后动态血压各参数明显降低（P〈0.05）,尤其是夜间血压参数（P〈0.01）,同时HRV各参数明显改善（P〈0.05）.结论 伴焦虑抑郁的高血压患者抗焦虑抑郁治疗不仅有利于降低平均血压,也可改善血压昼夜节律及HRV.

Effects of anti-anxiety depression drugs on antihypertensive therapy and AMBP and HRV in patients with essential hypertension combined anxiety and depression

Objective To investigate the effects of anti-anxiety depression drug on antihypertensive therapy and ambulatory blood pressure and HRV in essential hypertensive patients with anxiety and depression. Methods Eighty essential hypertensive patients with anxiety and depression were randomly divided into two groups：control group （routine antihypertensive drugs and VitB6） and experimental group （routine antihypertensive drugs and anti-anxiety depression drug）,to follow up for 6 weeks. ABPM and HRV were compared between experimental group and control groups. Results The 24 hours average blood pressure, the average blood pressure of daytime,the average blood pressure of night of two groups decreased on post treatment （P〈0.05）, but it is significant between experimental group and control group （P〈0.05）,and the average blood pressure of night on experimental group was higher obviously （P〈0.01）.the HRV of two groups increased on post treatment （P〈0.05）, but it is significant between experimental group and control group（P〈0.05 ）. Conclusion The antianxiety and anti-depressant treatment has effect on antihypertensive therapy and circadian rhythm of ambulatory blood pressure and HRV in essential hypertensive patients with anxiety and depression.