| 盐酸托烷司琼胶囊的研制 |
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| 引用本文： | 黄桂华,高彦慧,张娜,王春香. 盐酸托烷司琼胶囊的研制[J]. 中国医药工业杂志, 2003, 34(8): 397-399 |
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| 作者姓名： | 黄桂华 高彦慧 张娜 王春香 |
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| 作者单位： | 山东大学药学院,济南,250012 |
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| 摘 要： | 以淀粉为主要填充剂，采用不同工艺制备盐酸托烷司琼胶囊。用高效液相色谱法测定其含量，小杯法测定胶囊体外溶出度。结果表明，过40目筛制细颗粒填装胶囊，颗粒流动性好，胶囊溶出均一性好，装量差异及含量均匀度均符合药典规定要求。
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| 关 键 词： | 盐酸托烷司琼 胶囊 高效液相色谱法 |
| 文章编号： | 1001-8255(2003)08-0397-03 |
| 修稿时间： | 2002-03-11 |
Preparation and in vitro Dissolution of Tropisetron Hydrochloride Capsules |
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| HUANG Gui-Hua,GAO Yan-Hui,ZHANG Na,WANG Chun-Xiang. Preparation and in vitro Dissolution of Tropisetron Hydrochloride Capsules[J]. , 2003, 34(8): 397-399 |
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| Authors: | HUANG Gui-Hua GAO Yan-Hui ZHANG Na WANG Chun-Xiang |
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| Abstract: | The tropisetron hydrochloride capsules were prepared by different methods with starch as main excipient. The tropisetron hydrochloride content was determined by HPLC, and the percentage of dissolution was evaluated. The results showed that granules prepared with screen size 40 had good mobility. Dissolution, the capacity diversity and the content uniformity of the capsules prepared with these granules were conformable to the requirements of pharmacopeia. |
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| Keywords: | tropisetron hydrochloride capsule HPLC |
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