多发伤患者血清降钙素原水平变化及临床意义

目的研究多发伤患者血清降钙素原(PCT)水平的变化,并探讨其与损伤严重程度、感染及多器官功能障碍综合征(MODS)的关系。方法检测64例多发伤患者伤后第1、3、5天血清PCT水平,同时进行损伤严重程度评分(ISS),记录血常规、血糖、血清丙氨酸转氨酶(ALT)、肌酐(Cr)、感染和MODS的情况。结果多发伤患者血清PCT水平显著高于正常对照组(P<0.01)。MODS组PCT、白细胞计数、ISS、血糖、ALT和Cr均明显高于脏器功能正常组(P均<0.05);发生感染前后,PCT水平差异有统计学意义(P<0.01)。结论多发伤可引起PCT水平升高,且与损伤严重程度、感染、MODS有关;检测PCT水平变化有助于及早发现感染和预警MODS的发生。

The significance of serum procalcitonin in patients with multiple trauma

Objective To study the changes of serum procalcitonin (PCT) in the patients with multiple trauma and its relationships with injury severity score (ISS), infection and multiple organ dysfunction syndrome (MODS). Methods Serum PCT, glucose, ALT, Cr and blood routine examination were measured in 64 cases of multiple trauma at 1, 3 and 5 days respectively after injuries. ISS, infection and MODS condition were recorded. Results The level of serum PCT in patients with multiple trauma was much higher than that of normal control (P<0.01). The serum PCT, white blood cell count, ISS, blood glucose, ALT and Cr in the cases with MODS were all much higher than those with normal organ function (P<0.05); The level of PCT in multiple trauma patients before the infection was significantly different with that after the infection (P<0.01). Conclusion Multiple trauma may induce increasing of serum PCT, serum PCT is positively correlating with ISS, infection and MODS condition. To detect the level of serum PCT is helpful to make early diagnosis of the infection and warning the MODS in patients with multiple trauma.