| D1多巴胺受体与原发性高血压 |
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| 引用本文： | 李震,曾春雨,杨成明. D1多巴胺受体与原发性高血压[J]. 心血管病学进展, 2006, 27(5): 572-575 |
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| 作者姓名： | 李震 曾春雨 杨成明 |
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| 作者单位： | 1. 第三军医大学大坪医院心内科心血管病研究室,重庆,400042;解放军第148医院心内科,山东,淄博,255300
2. 第三军医大学大坪医院心内科心血管病研究室,重庆,400042 |
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| 摘 要： | 多巴胺可通过对肾脏水钠重吸收的调节作用,进而发挥对血压调控的影响,多巴胺功能障碍在原发性高血压发生过程中发挥重要的作用。在多巴胺受体的5个亚型中,D1受体的作用尤其引人注目。在体内钠负荷过载的情况下,刺激肾脏D1受体可调节超过50%的钠排量。原发性高血压状态下D1受体功能障碍,其发生的原因与D1受体/G蛋白效应物复合体失偶联有关,而其失偶联的机制归因于G蛋白激酶4变异体存在所引起的G蛋白激酶活性增高。
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| 关 键 词： | 多巴胺 D1多巴胺受体 尿钠排泄 近端小管 G蛋白激酶 |
| 文章编号： | 1004-3934(2006)05-0572-03 |
| 收稿时间： | 2005-10-21 |
| 修稿时间： | 2006-04-07 |
D1 Dopamine Receptor and Essential Hypertension |
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| LI Zhen,ZENG Chun-yu,YANG Cheng-ming. D1 Dopamine Receptor and Essential Hypertension[J]. Advances in Cardiovascular Diseases, 2006, 27(5): 572-575 |
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| Authors: | LI Zhen ZENG Chun-yu YANG Cheng-ming |
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| Affiliation: | 1. Department of Cardiology, Research Laboratory for Cardiology, Daping Hospital of The Third Military Medical University, Chongqing 400042, China; 2. Department of Cardiology,NO. 148 Military Hospital,P. R. China, Zibo 255300, China |
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| Abstract: | Dopamine receptor plays an important role in essential hypertension by regulating renal sodium and water excretion.D_1 dopamine receptor is the most important of the five dopamine receptor subtypes.Stimulation of D_1 receptor can control more than 50% of sodium excretion from the body in the sodium-replete states.D_1 receptor function is impaired in essential hypertension states,which is due to the uncoupling of D_1 receptor and G protein-effector.G protein related kinase 4 mutants increase G protein related kinase activity,which,in turn,leads to the uncoupling of D_1 receptor and G protein-effectors. |
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| Keywords: | dopamine D_1 dopamine receptor natriuesis proximal tubule G protein related kinase |
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