呼吸衰竭患者甲状腺激素水平的变化及临床意义

目的探讨呼吸衰竭患者甲状腺激素水平的变化情况及临床意义。方法选取在我院就诊的96例呼吸衰竭患者作为研究对象，按病情分为急性呼吸衰竭组（45例）和慢性呼吸衰竭组（51例），同时选取健康体检的正常人（48例）作为对照组，分析比较三组对象的总三碘甲状腺原氨酸（n）、总甲状腺激素（n）、游离三碘甲状腺原氨酸（n）、游离甲状腺素（n）、促甲状腺激素（TSH）水平。结果与对照组相比，急性呼吸衰竭组患者，TT3、TT4、FTT3、FT4水平均低于对照组（P〈0．01），TSH水平高于对照组（P〈0．01）；慢性呼吸衰竭组患者TT3、TT4、FT3均低于对照组（P〈0．01），而FT4和TSH水平无明显差异（P〉0．05）；急性呼吸衰竭组患者TSH水平高于慢性呼吸衰竭组（P〈0．01）。结论对呼吸衰竭患者进行甲状腺激素水平的测定，有助于对疾病的评估治疗。

The change of thyroid hormones and clinical significance in patients with respiratory failure

Objective To analyze the change of thyroid hormones and clinical significance in patients with respiratory failure. Methods A total of 96 patients with respiratory failure were enrolled into this study. There were 45 patients in acute group and 51 in chronic group. Fourth-eight healthy subjects were enrolled into this study as the control group. The following parameters of the patients among the three groups were compared and analyzed： total tri-iodothyroxine （TT3 ） , total thyroxine （ TT4 ） , free tri-iodothyroxine （ FT3 ） , free thyroxine （ FT4 ） and thyrotropin （TSH） levels. Results Compared with the control group, the TT3,TT4, FT3 and FT4 of the pa- tients with acute respiratory failure were significantly lower and the TSH higher（ P 〈 0.01 ）. Compared with the control group, the TT3, TT4 and FT3 of the patients with chronic respiratory failure were significantly lower（ P 〈 0.01 ）. There was no significant differences in TSH levels of the two groups when compared with the control group（ P 〉 0.05 ）. Compared with the chronic respiratory failure patients, the TSH level was significantly higher（ P 〈 0.01 ）. Conclusion The measurement for thyroid hormone of patients with repiratory failure which is helpful evaluating and controling the patients＇ condition has clinical significante. Severity of patients with respiratorg failure.