凉血消风汤加减治疗血热型银屑病的疗效及对外周血白介素-8的影响

[目的]探讨凉血消风汤加减治疗血热型银屑病的机制及对外周血白介素-8(IL-8)水平的影响。[方法]采用酶联免疫吸附试验(ELISA)法观察了40例血热型银屑病患者应用凉血消风汤治疗前后外周血IL-8水平的变化,同时观察了凉血消风汤的疗效。[结果]血热型银屑病患者外周血IL-8水平明显高于对照组(P0.01);治疗8周后,血热型银屑病患者外周血IL-8明显降低,与治疗前比较差异有统计学意义(P0.01),治疗后PASI(银屑病皮损面积和严重程度指数)评分较治疗前明显降低(P0.01)。[结论]凉血消风汤治疗血热型银屑病有效,可能通过降低IL-8的水平,抑制中性粒细胞及T淋巴细胞聚集,减轻局部炎症,从而减轻血热型银屑病的症状。

Therapeutic effect of modified Liangxue Xiaofeng decoction and effect on peripheral interleukin-8 in patients with psoriasis with blood heat syndrome

[Objective] To explore the therapeutic mechanism of modified Liangxue Xiaofeng decoction and the effect on interleukin-8(IL-8) of peripheral blood in patients with psoriasis with blood heat syndrome. [Methods] The level of IL-8 before and after treatment by modi-fied of Liangxue Xiaofeng decoction for 8 weeks was measured in patients by ELISA methods. [Results] IL-8 of peripheral blood were higher in patients than that in controls (P<0.01). After treatment, IL-8 of peripheral blood and the PASI were lower than that before (P<0.01). [Conclusion] The modified of Liangxue Xiaofeng decoction may reduce psoriatic symptoms by reducing the activation of com-plement and inhibiting the inflammation reaction.