| CTLA-4单克隆抗体——靶向被动免疫治疗肿瘤 |
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| 引用本文： | 周艳,董文. CTLA-4单克隆抗体——靶向被动免疫治疗肿瘤[J]. 临床肿瘤学杂志, 2013, 18(3): 268-272 |
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| 作者姓名： | 周艳 董文 |
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| 作者单位： | 410011.长沙 中南大学湘雅二医院肿瘤科 |
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| 摘 要： | 细胞免疫在机体对恶性肿瘤的免疫应答中发挥重要作用。人细胞毒性T淋巴细胞相关抗原4（CTLA-4）通过抑制T细胞的激活，参与T细胞免疫耐受的诱导和维持。因此通过单克隆抗体阻断CTLA-4 的作用，可刺激免疫细胞大量增殖，从而增强机体对肿瘤的免疫反应。本文主要综述了近年来CTLA-4单克隆抗体药物（Ipilimumab、Tremelimumab）的研究及其在临床的应用进展。
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| 关 键 词： | CTLA-4 单克隆抗体 靶向免疫治疗 |
| 收稿时间： | 2012-10-29 |
| 修稿时间： | 2012-12-11 |
CTLA-4 monoclonal antibody-targeted passive immunotherapy for tumor |
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| ZHOU Yan , DONG Wen. CTLA-4 monoclonal antibody-targeted passive immunotherapy for tumor[J]. Chinese Clinical Oncology, 2013, 18(3): 268-272 |
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| Authors: | ZHOU Yan DONG Wen |
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| Affiliation: | Department of Oncology，the Second Xiangya Hospital of Central South University，Changsha 410011，China |
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| Abstract: | Cellular immune system plays a very important role in the body＇s immune response to malignant tumor. Cytotoxic T lymphocyte-associated antigen 4 （CTLA-4） involves in the induction and maintenance of T cell immune tolerance through inhibiting T cell activity, so the monoclonal antibody which blocks the CTLA-4 can stimulate the proliferation of immune cells, thereby enhances the body＇s immune response to the tumor. This paper mainly reviews the research progresses about CTLA4 monoclonal antibody drugs（ ipil- imumab and tremelimumab） in recent years and the clinical application progress of them. |
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| Keywords: | CTLA-4 Monoclonal antibody Targeted immunotherapy |
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