参松养心胶囊对原发性高血压患者心率变异性的影响

目的 探讨参松养心胶囊对原发性高血压患者心率变异性的影响.方法 将68例原发性高血压患者随机分为2组.对照组32例,应用常规降压药物治疗;治疗组(参松养心胶囊组)36例,在高血压治疗的基础上加用参松养心胶囊0.12 g,每天3次,疗程为4周.于治疗前和治疗后4周行24 h动态心电图检查测定其心率变异性时域分析指标.结果 治疗组时域分析指标24 h内正常窦性R-R间期值的标准差(126.4±26.1 ms比110.8±17.9 ms)、24 h内连续每5 min正常R-R间期平均值的标准差(108.4±28.8 ms比98.2±16.2 ms)、24 h内相邻R-R间期差的平方根(28.7±15.2 ms比26.4±15.1 ms)、24 h内相邻正常R-R间期差值大于50 ms的计数占总R-R间期的百分比(8.2%±7.1%比5.9%±5.3%)均较对照组明显提高(P<0.05).结论 参松养心胶囊能显著改善原发性高血压患者心率变异性,改善其预后.

The Influence of Shensongyangxin Capsule on Heart Rate Variability in Patients with Essential Hypertension

Aim To investigate the influence of Shensongyangxin capsule on heart rate variability(HRV) in patients with essential hypertension. Methods 68 patients with essential hypertension were randomly divided into 2 groups.32 patients with conventional antihypertensive drug treatment(control group) and 36 patients with Shensongyangxin capsule 0.12 g,3 times/d,4 weeks based on the conventional antihypertensive drug(treatment group).The HRV and the time domain analysis indicator with Holter ECG were measured and analyzed before and 4 weeks after treatment. Results Compared with control group,the standard deviation of normal-to-normal intervals(SDNN)(126.4±26.1 ms vs 110.8±17.9 ms),within 24 h each successive 5 min normal R-R intervals average of standard deviation(SDANN)(108.4±28.8 ms vs 98.2±16.2 ms),rate-mean-square of the difference of successive R-R interval(rMSSD)(28.7±15.2 ms vs 26.4±15.1 ms) and within 24 h nearby normal R-R interphase sent a value greater than the count of 50 ms total R-R interval percentage(PNN50%)(8.2%±7.1% vs 5.9%±5.3%) were significantly increased in treatment group(P><0.05). Conclusion Shensongyangxin capsule can significantly improve the HRV and the prognosis in the patients with essential hypertension.