维生素D和高血压发病的研究进展

维生素D缺乏非常普遍,流行病学和临床研究显示维生素D缺乏可能和高血压发病有关.维生素D可能通过负性调节肾素血管紧张素系统,减少甲状旁腺素分泌,改善胰岛素抵抗及对血管的保护作用降低高血压的发病风险,而且维生素D受体基因多态性也可能和高血压相关.开展维生素D和高血压发病的研究可能对高血压防治提供新的途径.

Recent Advances in Vitamin D and Hypertension

Vitamin D deficiency is very common in Chinese.Recent epidemiological studies have demonstrated strong association between vitamin D deficiency and risk of hypertension.The mechanism for how vitamin D protect against hypertension has not been fully elucidated.Proposed mechanisms include effects on negative regulation of renin-angiotensin system,on decreasing secretion of parathyroid hormone,on improving insulin resistance as well as direct effects on vasculature.In addition,genetic variants of vitamin D receptor were also the risk factors of human hypertension.Further study on vitamin D and human hypertension will improve the prevention and treatment of hypertension.