乙型肝炎病毒感染与肝硬变关系的探讨

报告经病理确诊为肝硬变140例,证明HBVM阳性占81.5％,HE染色均见慢活肝病理特点,Victoria blue染色在血清HBVM阳性、HBsAg阴性和未查HBVM病例中,肝组织内能检出HBsAg者分别为77.6％、66.7％和60.0％,三者无明显差异。说明肝硬变患者血清HBsAg阴性并不能除外HBV感染可能。因此,认为我国肝硬变与HBV感染间存在密切因果关系,是HBV感染后慢活肝的一种结局,预防肝硬变主要应在预防HBV感染和慢活肝的治疗。

A STUDY ON RELATIONSHIP BETWEEN HBV INFECTION AND LIVER CIRRHOSIS

It was observed that in 81.5% of 140 cases with liver cirrhosis, the serum was HBVM positive, and the liver biopsy showed characteristic features of CAH. HBsAg could be detected with VB stains in 77.6% of HBVM seropositive cases, 66.7% of HBsAg seronegative cases, and 60.0% of the cases whose serum HBVM had not been examined. There was no significant difference among them statistically. It was our belief that negative serum HBsAg did not rule out the posibility of HBV infection in liver cirrhosis patients. Our observations suggested that there might be a very close relationship between HBV infection and liver cirrhosis in our country, and liver cirrhosis was the outcome of HBV infection. Therefore, in the prevention of liver cirrhosis it should be emphasized that HBV infection should be prevented and CAH well treated.