HPV6型E7在尖锐湿疣初发与复发组织中的表达

目的本研究旨在分析HPV6型早期蛋白E7在尖锐湿疣初发、复发与正常组织中的表达情况,以探讨早期蛋白E7在尖锐湿疣病情转归中的生物学意义。方法采用u ltrasensitiveTM s-p免疫组化法对56例初发尖锐湿疣患者的活检组织,35例复发尖锐湿疣患者的活检组织及27例正常宫颈上皮组织中的HPV6型E7蛋白的表达情况进行测定。结果56例初发尖锐湿疣患者HPV6型E7蛋白的阳性表达率为69.5%,35例复发性尖锐湿疣患者的活检组织中HPV6型E7蛋白的阳性表达率为71.4%,27例正常宫颈上皮组织中HPV6型E7蛋白的阳性表达率为0。尖锐湿疣患者初发与复发组织的HPV6型E7蛋白表达和正常宫颈上皮组织相比均有显著性差异(P<0.001)。结论HPV6型早期蛋白E7与尖锐湿疣的发生密切相关,在尖锐湿疣的发展中也起着重要的作用,与其复发存在一定的关系,但没有统计学意义。HPV6型早期蛋白E7与尖锐湿疣的病情转归的联系尚需进一步研究。

Expression of HPV6-E7 Oncoprotein in Incipient and Relapse Condyloma Acuminatum Tissues

Objective This study was designed to determine the expression of HPV6-E7 oncoprotein in normal cervix uteri tissues,incipient condyloma acuminatum tissues and relapse condyloma acuminatum tissues,and to investigate the biological significance of HPV6-E7 in conversion of condyloma acuminatum.Methods HPV6-E7 was determined using immunohistochemical staining in normal cervix uteri tissues(27 cases),incipient condyloma acuminatum tissues(56 cases) and relapse condyloma acuminatum tissues(35cases).Results The positive rates of HPV6-E7 in the tissues of normal cervix uteri,incipient condyloma acuminatum and relapse condyloma acuminatum were 0,69.5%and 71.4%,respectively.The positive rates of HPV6-E7 in incipient and relapse condyloma acuminatum tissues were significantly higher than those in normal cervix uteri(P<0.001).Conclusion The results suggest that HPV6-E7 is correlative with the invasion of condyloma acuminatum,and it also plays an important role in the development of condyloma acuminatum.Though there is some relation with its relapse,they have no statistical significance.It needs further study for the relation between HPV6-E7 and the conversion of condyloma acuminatum.