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Central injection of astressin inhibits carbon tetrachloride-induced acute liver injury in rats |
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| Authors: | Nakade Yukiomi Yoneda Masashi Yokohama Shiro Tamori Keisuke Nakamura Kimihide Watanobe Hajime Kono Toru Makino Isao Terano Akira |
| Affiliation: | a Second Department of Medicine and Surgery, Asahikawa Medical College, Asahikawa, Japan b Department of Gastroenterology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Tochigi 321-0293, Japan c Center for Clinical Research, International University of Health and Welfare, Otawara, Japan |
| Abstract: | The effect of intracisternal astressin, a specific and potent corticotropin-releasing factor (CRF)1 and CRF2 receptor antagonist on carbon tetrachloride (CCl4)-induced acute liver injury was investigated in rats. Intracisternal astressin inhibited the elevation of serum alanine aminotransferase level induced by CCl4. Intracisternal astressin also reduced CCl4-induced liver histological changes. The protective effect of central astressin on CCl4-induced liver damage was abolished by sympathectomy but not by hepatic branch vagotomy. These findings demonstrate that astressin acts in the central nervous system to induce hepatic cytoprotection, possibly through the sympathetic pathways in rats. These results further establish a role of endogenous CRF in the brain in hepatic pathophysiological regulation. |
| Keywords: | Astressin Hepatic sympathectomy Central nervous system Liver injury |
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