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Somatic cell hybrids between Friend erythroleukemia cells and mouse hepatoma cells
Authors:Jean -François Conscience  Frank H Ruddle  Arthur Skoultchi  Gretchen J Darlington
Institution:(1) Biology Department, Kline Biology Tower, Yale University, 06520 New Haven, Connecticut;(2) Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461 Bronx, New York;(3) Department of Medicine, Cornell University Medical College, 10021 New York, New York
Abstract:Somatic cell hybrids between hepatoma and Friend erythroleukemia parental cells were studied for the expression of liver-specific and erythroid properties. Several independent clones were isolated using HAT selection and were shown to be true hybrids by isozyme and chromosome analysis. All displayed a complete extinction of hemoglobin and globin mRNA production, but a retention of albumin and transferrin secretion. The data suggest that erythroid differentiation is being actively inhibited by the hepatoma genome. Possible mechanisms that might explain these results are discussed in the light of current hypotheses regarding the mechanism of cell differentiation.
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