| 伐昔洛韦分散片的处方筛选研究 |
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| 引用本文： | 李玉珍,徐玉红,李成,王蔓琳. 伐昔洛韦分散片的处方筛选研究[J]. 中国药房, 2006, 17(23): 1772-1773 |
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| 作者姓名： | 李玉珍 徐玉红 李成 王蔓琳 |
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| 作者单位： | 深圳市第四人民医院药剂科,深圳市,518033 |
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| 摘 要： | 目的:筛选和优化伐昔洛韦分散片的处方。方法:以崩解时限为考察指标,以交联聚乙烯吡咯烷酮(PVPP)浓度及加入方法、粘合剂聚维酮(PVP-K30)浓度、羧甲基淀粉钠(CMS-Na)的用量为因素,采用L9(34)正交试验表设计试验方案,对伐昔洛韦分散片处方进行筛选,并与普通片进行体外溶出度比较。结果:最佳处方为PVPP(内加)4.0%、PVP-K301.0%、CMS-Na5.0%;按优化处方制备的伐昔洛韦分散片在3min内完全崩解,溶出度明显优于普通片。结论:优化处方达到《中国药典》规定要求。
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| 关 键 词： | 伐昔洛韦 分散片 处方筛选 正交设计 |
| 文章编号： | 1001-0408(2006)23-1772-02 |
| 收稿时间： | 2006-08-17 |
| 修稿时间： | 2006-09-20 |
On Formula Optimization for Valaciclovir Dispersible Tablets |
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| LI Yuzhen,XU Yuhong,LI Chen,WANG Manlin. On Formula Optimization for Valaciclovir Dispersible Tablets[J]. China Pharmacy, 2006, 17(23): 1772-1773 |
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| Authors: | LI Yuzhen XU Yuhong LI Chen WANG Manlin |
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| Abstract: | OBJECTIVE:To optimize the formula of valaciclovir dispersible tablets.METHODS:A L 9(3 4)orthogonal design was performed to optimize the formula of valaciclovir dispersible tablets with disintegrating time as parameter of investigation,and with the concentration of crospovidone(PVPP)and the method of its adding,the concentration of binder polyvidone(PVP-K 30)and the dosage of sodium carboxymethyl starch(CMS-Na)as factors,the dissolution of dispersible tablets was compared with common tablets.RESULTS:The optimized formula were the following,PVPP(added internally)4.0%,PVP-K 30 1.0% and CMS-Na 5.0%.The optimized valaciclovir dispersed tablets disintegrated completely within 3 min,its dissolu-bility was turned out to be superior to that of the common tablets.CONCLUSION:The dissolution of the optimized dispersed tablets is up to the standard of Chinese Pharmacopoeia. |
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| Keywords: | Valaeiclovir Dispersible tablet Formula optimization Orthogonal design |
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