特殊类型银屑病伴发高尿酸血症相关因素分析

目的:探讨特殊型银屑病伴发高尿酸血症的相关因素。方法:对117例红皮病型、泛发性脓疱型或/及关节病型银屑病患者的临床资料进行回顾性分析;根据尿酸代谢过程、影响因素、银屑病的临床表现等确定分析指标15项,对高尿酸血症组、正常组间各指标先后进行单因素分析及多因素Logistic回归分析;同时分析特殊用药、病情演变与患者血尿酸水平变化间的关系。结果:特殊类型银屑病伴高尿酸血症发生率为31.62%;高尿酸血症组与正常组比较,性别、红皮病型损害、泛发性脓疱型损害及血甘油三酯增高间的差异均有统计学意义(P<0.05);红皮病型损害、男性、甘油三酯增高、泛发性脓疱型损害是影响高尿酸血症发生的重要因素,其相对危险度(RR)依次为8.93、6.83、2.86、0.31。结论:特殊型银屑病伴发高尿酸血症可能与性别、红皮病型损害、泛发性脓疱型损害、甘油三酯增高及特殊用药有关。

Analysis of the factors related to hyperuricemia in patients with special types of psoriasis

Objective:To determine the factors related to hyperuricemia in patients with special types of psoriasis. Methods: One hundred and seventeen cases with psoriasis erythrodermia, generalized pustular psoriasis and/or psoriasis arthropathica were analyzed retrospectively; the factors related to hyperuricemia were determined by univariate and multivariate logistic regression according to the metabolic process of serum uric acid and the clinical manifestation of psoriasis. The correlation between serum uric acid level and special medication or patients' condition succession was also analyzed. Results: The incidence of hyperuricemia in the patients with special types of psoriasis was 31.62%. There were statistically significant differences between the hyperuricemia group and normal uric acid group with regard to gender, erythroderma, generalized pustula and hypertriglyceidemia (P<0.05). Erythroderma, gender (male), hypertriglyceidemia and generalized pustula were considered as essential factors in the occurrence of hyperuricemia, the relative risks were 8.93, 6.83, 2.86, 0.31 respectively. There existed potentially some causality between hyperuricemia and special medication. Conclusion: The occurrence of hyperuricemia in the patients with special types of psoriasis may relate to gender (male), erythroderma, generalized pustula, hypertriglyceidemia and special medication.