| 先天性心脏病合并肺动脉高压患儿手术前后血硫化氢及血红蛋白氧合酶-1变化的意义 |
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| 引用本文： | 张晓荣,戎小平. 先天性心脏病合并肺动脉高压患儿手术前后血硫化氢及血红蛋白氧合酶-1变化的意义[J]. 实用儿科临床杂志, 2010, 0(6) |
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| 作者姓名： | 张晓荣 戎小平 |
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| 作者单位： | 迁安市妇幼保健院儿科;河北医科大学第四医院儿科; |
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| 基金项目： | 河北省科技厅科技支撑计划项目(0727611001) |
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| 摘 要： | 目的探讨先天性心脏病(CHD)合并肺动脉高压(PH)患儿手术前后硫化氢(H2S)及血红蛋白氧合酶-1(HO-1)的变化及其临床意义。方法选取河北医科大学第四医院心脏外科收治的48例左向右分流的CHD患儿,均在复合麻醉中成功实施了根治手术。48例患儿行心脏多普勒术前测压,按照肺动脉收缩压高低(PASP)分为3组:无PH组(PASP<3.990kPa)15例,轻度PH组(PASP3.990～6.517kPa)15例,中重度PH组(PASP≥6.650kPa)18例。于术前、术后1h及术后24h采集各组患儿桡动脉血标本,用吸光度法测定血浆H2S水平,用双波长分光光度法测定血清HO-1活性。数据分析采用重复测量数据的方差分析、多因素方差分析、直线相关分析。结果各组患儿术后H2S水平呈上升趋势,术后24h与术前比较差异均有统计学意义(Pa<0.05)。术前、术后1h及术后24h,中重度PH组、轻度PH组血浆H2S水平均显著低于无PH组(Pa<0.05),中重度PH组血浆H2S水平均显著低于轻度PH组(Pa<0.05);术前、术后1h、术后24h,3组患儿血清HO-1活性比较差异无统计学意义;3组患儿血清HO-1活性组间...
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| 关 键 词： | 肺动脉高压 先天性心脏病 硫化氢 血红蛋白氧合酶-1 |
Changes of Hydrogen Sulfide and Heme Oxygenase-1 of Children with Congenital Heart Disease Combined with Pulmonary Hypertension and Those Significances |
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| ZHANG Xiao-rong,RONG Xiao-ping. Changes of Hydrogen Sulfide and Heme Oxygenase-1 of Children with Congenital Heart Disease Combined with Pulmonary Hypertension and Those Significances[J]. Journal of Applied Clinical Pediatrics, 2010, 0(6) |
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| Authors: | ZHANG Xiao-rong RONG Xiao-ping |
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| Affiliation: | ZHANG Xiao-rong1,RONG Xiao-ping2(1.Department of Pediatrics,Qian'an Maternal , Child Care Hospital,Qian'an 064400,Hebei Province,China,2.Department of Pediatrics,the Forth Hospital of Hebei Medical University,Shijiazhuang 050011,China) |
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| Abstract: | Objective To explore the clinical significance of hydrogen sulfide(H2S)and heme oxygenase-1(HO-1)on pulmonary hypertension(PH),by detecting their levels of patients with congenital heart disease(CHD).Methods Forty-eight patients with CHD who had left-to-right shunt were selected randomly from cardiac surgery in the Fourth Hospital of Hebei Medical University.Forty-eight patients were performed successfully on radical operation under complex intravenous anesthesia,and they were divided 3 groups according to ... |
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| Keywords: | pulmonary hypertension congenital heart disease hydrogen sulfide heme oxygenase-1 |
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