| 肟类重活化剂对抗氧化乐果抑制离体大鼠膈肌的研究 |
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| 引用本文： | 王汉斌,赵德禄.肟类重活化剂对抗氧化乐果抑制离体大鼠膈肌的研究[J].军事医学科学院院刊,1997,21(3):205-207. |
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| 作者姓名： | 王汉斌 赵德禄 |
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| 作者单位： | 军事医学科学院附属医院 |
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| 摘 要： | 在离体大鼠膈神经－膈肌标本（膈ＮＭＰ）上观察了和的肟类重活化剂氯磷定碘磷定、双复磷和ＨＩ－６对抗氧化氯对标本的抑制作用，发现４种药物在对抗氧化乐果抑制离体大鼠膈ＮＭＰ的作用中均有对中毒酶的重活化作用，其强弱排序为：双复磷〉氯磷定、碘磷定〉ＨＩ－６。ＨＩ－６具有较强的直接生理对抗作用。
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| 关 键 词： | 肟类 乐果 大鼠 膈神经 解毒剂 农药中毒 |
Study on the neuromuscular recovery induced by reactivators in isolated inhibited rat diaphragmatic muscle following omethoate poisoning |
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| Wang Hanbin,Zhao Delu,Huang Shaoqing Research Clinic,Academy of Military Medical Sciences,Beijing.Study on the neuromuscular recovery induced by reactivators in isolated inhibited rat diaphragmatic muscle following omethoate poisoning[J].Bulletin of the Academy of Military Medical Sciences,1997,21(3):205-207. |
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| Authors: | Wang Hanbin Zhao Delu Huang Shaoqing Research Clinic Academy of Military Medical Sciences Beijing |
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| Institution: | Wang Hanbin,Zhao Delu,Huang Shaoqing Research Clinic,Academy of Military Medical Sciences,Beijing 100039 |
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| Abstract: | The antagonistic effects of the common oximes PAM Cl, PAM I, obidoxime and HI 6 on inhibition of the isolated rat phrenic neuromuscular transmission by omethoate were observed and it was found that all the four kinds of oximes could reactivate ChE inhibited by omethoate in rat phrenic nerve diaphragm preparation in vitro. The order of the reactivation potency was : obidoxime>PAM Cl, PAM I>HI 6; meanwhile, HI 6 showed a strong direct physiological antagonistic. |
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| Keywords: | oximes omethoate rat phrenic nerve antidotes |
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