尿酸与慢性肾脏疾病（CKD）研究近况

尽管高尿酸水平通常与CKD有关联，但高尿酸血症本身是否是CKD发展或者恶化的真正危险因素仍存在争议。近来流行病学对健康及有肾脏疾病的人群研究报道，尿酸有降低肾小球滤过率及增加新发肾脏疾病危险的作用。而且，有报道称，肾脏疾病患者经过降尿酸治疗后可以稳定肾功能，且独立于其他影响肾功能的多种因素，表明高尿酸水平是CKD进展的原因。本文以流行病学，临床及实验室研究为根据，讨论在CKD进展及恶化中尿酸的潜在作用。

The Research Status of Uric Acid and Chronic Kidney Disease

Although the high uric acid levels usually associated with CKD, it remained controversial whether hyperuricemia was the risk factor of the CKD development or deterioration, which was likely to lower of the true risk factor. It was reported in recent epi- demiologic studies of healthy populations and patients with kidney disease that the uric acid was the very factor which was likely to lower glomerular filtration rate and increase the risk of developing kidney disease. Moreover, lowering uric acid （independent of other influ- encing factors）, according to the report, is useful for patients with established renal disease to stabilize renal function, manifesting that uric acid is the reason of CKD progression. In this paper we will discuss the potential role of uric acid in the development and aggrava- tion of CKD based on epidemiologic, clinical and experimental studies.