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| 肝前型门静脉高压兔门脉系统血管应力的研究 | |
| 引用本文： | 张宗棨,汤松伟,朱樑,吴国强,姜宗来,施斌.肝前型门静脉高压兔门脉系统血管应力的研究[J].生物医学工程学杂志,2008,25(6). |
| 作者姓名： | 张宗棨 汤松伟 朱樑 吴国强 姜宗来 施斌 |
| 作者单位： | 1. 第二军医大学,长征医院,消化内科,上海,200003 2. 复旦大学,力学与工程科学系,上海,200433 3. 上海交通大学,医学院,生物力学实验室,上海,200030 |
| 基金项目： | 第二军医大学青年启动基金资助项目 |
| 摘 要： | 门脉高压症是肝硬化常见的病理生理改变.本研究采用两步门静脉结扎法制备门脉高压症(PHT)兔模型;检测不同时间点门静脉及小肠系膜曲张静脉的直径,不同程度曲张静脉及门静脉主干的血流动力学和应力(压力、剪应力和周向应力)大小.随着小肠系膜曲张静脉直径的增大,PHT兔门脉与小肠系膜静脉压力显著增加,剪应力减小,周向应力增大;两部位间应力(压力、剪应力和周向应力)呈直线正相关.研究表明,门脉高压时门脉系统处于低剪应力与高周向应力状态,这可能是门脉高压症并发症发生的力学基础. |
| 关 键 词： | 门静脉高压症 压力 剪应力 周向应力 门静脉高压兔 |
Stresses in Portal Venous System of Pre-hepatic Portal Hypertension(PHT) Rabbits |
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| Zhang Zongqi,Tang Songwei,Zhu Liang,Wu Guoqiang,Jiang Zonglai,Shi Bin.Stresses in Portal Venous System of Pre-hepatic Portal Hypertension(PHT) Rabbits[J].Journal of Biomedical Engineering,2008,25(6). | |
| Authors: | Zhang Zongqi Tang Songwei Zhu Liang Wu Guoqiang Jiang Zonglai Shi Bin |
| Institution: | Department of Gastroenterology;Changzheng Hospital;Second Military Medical University;Shanghai 200003;China;Department of Mechanics& Engineering Science;Fudan University;Shanghai 200433;China;Laboratory of Biomechanics;Medical School;Shanghai Jiaotong University;Shanghai 200030;China |
| Abstract: | Portal hypertension is a common physiopathological change in liver cirrhosis.In this study,rabbits were used and the model of pre-hepatic portal hypertension(PHT) was induced by partial ligation of portal vein in two steps.We measured the diameters of portal vein and small mesenteric vein at different time-points.Then we detected the stress forces induced by blood flow in varicose veins and in portal vein;such forces included hydrostatic pressure,shear stress and circumferential stress.With the increase of ... |
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