108例儿童慢性咳嗽的病原学分析

目的分析小儿慢性咳嗽病原学特点和分布规律,有助于指导临床诊断和治疗。方法对我院2005年3月~2009年3月确诊的慢性咳嗽108例患儿取下呼吸道分泌物标本作细菌培养,取血清检测呼吸道病毒抗原和肺炎支原体、肺炎衣原体抗体IgM。结果检出病原体例数78例（占患儿例数72.2%）。其中一种病毒感染4例（3.7%）,两种以上病毒感染1例;一种细菌感染16例（14.8%）,两种以上细菌感染2例;单纯支原体感染29例（26.9%）;单纯衣原体感染9例（8.3%）;混合感染15例（13.9%）,其中细菌＋病毒2例,病毒＋支原体1例,细菌＋支原体4例,细菌＋衣原体3例,细菌＋病毒＋支原体2例,支原体并衣原体感染3例;肺结核1例,肺吸虫1例。未检出病原30例（27.8%）。结论感染因素仍是小儿慢性咳嗽的主要原因之一,其病原谱主要表现为革兰阴性菌和肺炎支原体或肺炎衣原体为主,存在较多混合感染。

Children chronic cough pathogeny investigation

Objectve To provide reference for the treatment and diagnose of children chronic cough by pathogeny investigation and category analysis of children with chronic cough. Methods Selected 108 cases of chronic cough in the Sichuan province women and children hospital from March 2005 to March 2009, detect the lower respiratory tract excretion the pathogen of chonic cough patient by detecting antigen of virus, bacteria and myeoplasma culture, and so on. Results Within the submitted 108 cases of lower respiratory tract excretion detection, it bad been detected 78 ones with pathogens. This mainly included 4 ones of one virus （ 3.7% ）, 16 ones of bacterium （ 14. 8% ）, 29ones of mycoplasma （ 26. 9 ）, 9 ones of chlamydia （ 8.3% ） two virus 3.7%. Conclusion Infection is the dominant cause for chronic cough ,while the pathogens spectrum are the Gram-negative bacterium and mycoplasma for widly using of antibiotic.