Effects of a Korean herbal formulation, Silsosangami, consisting of seven medicinal herbs, and its seven herbs on endotoxin-induced experimental thrombosis in rats |
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Authors: | Park Won-Hwan Ahn Jong-Chan Kim Hyung-Min Lee Young-Choon Kim Cheorl-Ho |
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Affiliation: | Department of Biochemistry, Molecular Biology and Diagnosis, Dongguk University COM and National Research Laboratory for Glycobiology, Korean Ministry of Science and Technology, KyungJu, Korea. |
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Abstract: | A traditional Korean medicine, Silsosangami (SSG), consisting of seven different herbs of Typhae Pollen, Pteropi Faeces, Paeoniae Radicis rubra, Cnidii Rhizoma, Persicae Semen, Carthami Flos and Curcumae Tuber, has been reported to have a hypolipidemic effect in human subjects. In the present study, the inhibitory effects of SSG on a thrombosis in rats, induced by endotoxin treatment were examined. The anti-thrombic properties of SSG were also investigated with respect to blood parameters. The extracts of SSG and five of the seven herbs, except Cnidii Rhizoma and Carthami Flos, inhibited both endotoxin-induced disseminated intravascular coagulation (DIC) and thrombosis in rats. The extract also inhibited the endotoxin-induced decrease in blood platelets and fibrinogen, and the endotoxin-induced increase in fibrin degradation products (FDP) on disseminated intravascular coagulation in normal rats. In conclusion, the artificially induced, protective effects of SSG on ischemic infarction might be related to their inhibitory effects on DIC, platelet coagulation and thrombotic action. |
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Keywords: | Silsosangami Typhae Pollen Pteropi Faeces Paeoniae Radicis rubra Cnidii Rhizoma Persicae Semen Carthami Flos Curcumae Tuber platelet aggregation antithrombosis endotoxin‐induced DIC blood platelet aggregation thrombin, fibrinogen fibrin plasminogen plasmin prothrombin time FDP |
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