| 线粒体DNA ND1基因T3394C点突变与2型糖尿病的关系 |
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| 引用本文： | 黄承乐,黄红华,丁凯宏. 线粒体DNA ND1基因T3394C点突变与2型糖尿病的关系[J]. 检验医学, 2011, 26(2): 122-124 |
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| 作者姓名： | 黄承乐 黄红华 丁凯宏 |
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| 作者单位： | 广西壮族自治区百色市人民医院,广西,百色,533000 |
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| 摘 要： | 目的探讨本地区汉族人群线粒体DNA ND1基因中T3394C突变与2型糖尿病（T2DM）的关系。方法应用聚合酶链反应（PCR）对无血缘关系的225例T2DM患者和190名正常对照者的外周血DNA进行PCR扩增并直接测序确证。结果糖尿病患者组中检出T3394C突变8例（3.56%）,正常对照组检出1名（0.53%）,2组间比较差异有统计学意义（P〈0.05）。结论线粒体DNA T3394C突变可能与本地区汉族人群T2DM的发生有关。
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| 关 键 词： | 线粒体ND1基因 2型糖尿病 基因突变 |
Association between T3394C point mutation in the mitochondrial DNA ND1 gene and type 2 diabetes mellitus |
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| HUANG Chengle,HUANG Honghua,DING Kaihong. Association between T3394C point mutation in the mitochondrial DNA ND1 gene and type 2 diabetes mellitus[J]. Laboratory Medicine, 2011, 26(2): 122-124 |
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| Authors: | HUANG Chengle HUANG Honghua DING Kaihong |
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| Affiliation: | .(Baise City People′s Hospital,Guangxi Baise 533000,China) |
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| Abstract: | Objective To study the relationship of T3394C point mutation in the mitochondrial DNA ND1 gene with type 2 diabetes mellitus（T2DM） in local Han people.Methods The peripheral blood DNA was amplified and sequenced in 225 T2DM patients and 190 controls by polymerase chain reaction（PCR）.Results There were 8 cases（3.56%）of T3394C mutation in T2DM patients and 1 case（0.53%）in controls.There was significant difference between the 2 groups（P0.05）.Conclusions The point mutation of T3394C in mitochondrial DNA could be related to the occurrence of T2DM in local Han people. |
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| Keywords: | Mitochondrial DNA ND1 gene Type 2 diabetes mellitus Gene mutation |
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