| 大鼠海马内强啡肽_(1-8)和亮啡肽在癫痫发作及电针时的变化 |
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| 引用本文： | 王布尔,程介士.大鼠海马内强啡肽_(1-8)和亮啡肽在癫痫发作及电针时的变化[J].中国药理学报(英文版),1994(2). |
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| 作者姓名： | 王布尔 程介士 |
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| 作者单位： | 上海医科大学神经生物学教研室 医学神经生物学国家重点实验室(王布尔)，上海医科大学神经生物学教研室 上海(程介士) |
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| 基金项目： | Project supported by the National Natural Science Foundation of China,№ 39170897. |
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| 摘 要： | 用免疫组织化学方法观察大鼠青霉素致痛及加电针后脑内强啡肽。及亮啡肽的变化。致痫时,在海马门区及苔样纤维上强啡肽含量明显减少,在海马下脚、CA_1区等结构内亮啡肽含量明显增加,电针后海马中强啡肽含量增加,亮啡肽含量在上述各区显著减少。提示:癫痫及电针抗痫可能与脑内强啡肽和亮啡肽的变化有关。
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| 关 键 词： | 强啡肽 亮啡肽 发作 海马 免疫组织化学 电针 |
Alteration of dynorphin 1-8 and leu-enkephalin in rat hippocampus during seizure and electroacupuncture |
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| WANG Bu-Er,CHENG Jie-Shi.Alteration of dynorphin 1-8 and leu-enkephalin in rat hippocampus during seizure and electroacupuncture[J].Acta Pharmacologica Sinica,1994(2). |
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| Authors: | WANG Bu-Er CHENG Jie-Shi |
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| Abstract: | Immunocytochemical technics were used to evaluate the influence of penicillin-induced seizure and electroacupuncture treatment on dynorphin1-8 and leu-enkephalin immunoreactivity in hippocampus. It was found that 3 h after beginning of seizure there started a dramatic decrease in dynorphin1-8 in hilus, mossy fiber of hippocampus but an increase in hilus, mossy fiber of hippocampus but an increase in leu-enkephalin in subicu-lum, CA1 area of hippocampus and some other limbic structures. Electroacupuncture treatment decreased the leu-enkephalin immunoreactivity in the nuclei mentioned above and increased dynorphin1-8 immunoreactivity in hippocampus. The results show that epilepti-form activity and electroacupuncture inhibitory effect on seizure may be related to the alteration of dynorphin1-8 and leu-enkephalin in the brain. |
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| Keywords: | dynorphin leucine enkephalin seizures hippocampus immunohisto - chemistry electroacupuncture |
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