| 使用手性冠醚的高效毛细管电泳法研究伯胺类药物的手性分离 |
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| 引用本文： | 夏小庆,方骏,金雅嫔.使用手性冠醚的高效毛细管电泳法研究伯胺类药物的手性分离[J].皖南医学院学报,2002,21(4):255-256. |
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| 作者姓名： | 夏小庆 方骏 金雅嫔 |
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| 作者单位： | 化学教研室 |
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| 摘 要： | 目的 采用HPCE法拆分伯胺类药物对映异构体。方法 缓冲液 2 0mmol/LTris 0 .1%H3 PO4(v/v)(pH 2 .0 6 ) +18 冠 6 四甲酸 (18C6H4) ;检测波长 2 10nm。结果 8种伯胺类药物得以拆分。结论 缓冲液中添加手性冠醚的HPCE法能较好地拆分伯胺类药物。
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| 关 键 词： | 立体异构现象 拆分 冠醚 电泳 毛细管 |
| 文章编号： | 1002-0217(2002)04-0255-03 |
| 修稿时间： | 2002年3月29日 |
Study on the Chiral Separation of Drugs Having a Primary Amino Group by HPCE with Chiral Crown Ether |
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| Xia Xiaoqing,Fang Jun,Jin Yapin.Study on the Chiral Separation of Drugs Having a Primary Amino Group by HPCE with Chiral Crown Ether[J].Acta Academiae Medicinae Wannan,2002,21(4):255-256. |
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| Authors: | Xia Xiaoqing Fang Jun Jin Yapin |
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| Abstract: | Objective\ Chiral separation of drugs having a primary amino group was studied by high performance capillary electrophoresis(HPCE) using 18C6H\-4 as the chiral selector. Methods\ The buffer consisting of 20 mmol/LTris+0.1%H\-3PO\-4(v/v)(pH 2.06)+10 mmol/L18C6H\-4 and a UV detector at 210 nm. Results\ Eight enantiomers tested were separated by HPCE. Conclusion\ Chiral separation of amino drugs by high performance capillary electrophoresis was successful with the addition of a chiral crown ether,18 crown 6 tetracarboxylic acid(18C6H\-4) |
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| Keywords: | stereoisomerism chiral separation grown ethers electrophoresis capillary |
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