Activation of PI3K/Akt signaling in rostral ventrolateral medulla impairs brain stem cardiovascular regulation that underpins circulatory depression during mevinphos intoxication |
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| Authors: | Ching-Yi Tsai Alice Y.W. Chang Julie Y.H. Chan Samuel H.H. Chan |
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| Affiliation: | Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan, ROC |
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| Abstract: | |
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| Keywords: | aCSF, artificial cerebrospinal fluid Akt, serine/threonine protein kinase EMSA, electrophoretic mobility shift assay HR, heart rate LF, low-frequency 3-MA, 3-methyladenine NF-κB, nuclear factor-κB NO, nitric oxide NOS, nitric oxide synthase NRS, normal rabbit serum PIP3, phosphatidylinositol-3,4,5-triphosphate PIP2, phosphatidylinositol-4,5-bisphosphate PI3K, phosphoinositide 3-kinase PH, pleckstrin homology PKB, protein kinase B PKG, protein kinase G PTEN, phosphatase and tensin homologue deleted on chromosome ten RVLM, rostral ventrolateral medulla SHR, spontaneously hypertensive rats TNF-α, tumor necrosis factor-α |
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