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Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin
Authors:Karin V Greco,Giovanna Nalesso,Magdalena K Kaneva,Joanna Sherwood,Asif J IqbalNiloufar Moradi-Bidhendi,Francesco Dell&rsquo  AccioMauro Perretti
Affiliation:The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom
Abstract:
Keywords:AB, Alcian Blue   ADAMT, A Disintegrin And Metalloproteinase with Trombospondin motif   AHAC, adult human articular chondrocyte   BAX, Bcl-2-associated X protein   BCL-2, B-cell leukemia-lymphoma-2 protein   BMP2, Bone Morphogenic Protein type 2   CT, Calcitonin   CTR, calcitonin receptor   CREB, cAMP response element-binding protein   ECM, extracellular matrix   EGFP, enhanced green fluorescent protein   FSK, forskolin   GAG, glycosaminoglycan   GPCR, G-protein coupled receptor   MMP, matrix metalloproteinase   NFAT, nuclear factor of the activated T-cells   OA, Osteoarthritis   PG, prostaglandin   PKA, protein kinase A   PLC, Phospholipase C   PRED, prednisolone   RA, Rheumatoid Arthritis   TUNEL, Terminal deoxynucleotidyl transferase dUTP nick end labeling.
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