Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis |
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| Authors: | Niels,Ø dum ,Niels,Morling ,Johannes,Friis ,Carsten,Heilmann ,Jens J.,Hyldig-Nielsen ,Bodil K.,Jakobsen ,Freddy Karup, Pedersen ,Per,Platz ,Lars P.,Ryder Arne,Svejgaard |
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| Affiliation: | The Copenhagen Study Group of Juvenile Chronic Arthritis: The Tissue Typing Laboratory of the Department of Clinical Immunology, Copenhagen, Denmark;department of Physical Medicine and Rehabilitation (Hornbæk), Copenhagen, Denmark;Department of Paediatrics G, State University Hospital (Rigshospitalet), Copenhagen, Denmark |
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| Abstract: | Thirty-six unrelated Danish patients with pauciarticular Juvenile Chronic Arthritis (PJCA) and 120 controls were typed for HLA-DPw1-w6 and the local specificity CDPHEI with bulk-expanded Primed Lymphocyte Typing (PLT) cells. The frequency of HLA-DPw2 was 52.8% in PJCA patients and 16.7% in controls (relative risk, RR = 4.5; P less than 0.001). The antigens HLA-Dw5 and/or Dw8 were present in 50% of the patients and in 21.3% of the controls (RR = 4.2; p less than 10(-3)). DPw2 was not associated (in linkage disequilibrium) with Dw5/w8 in patients or in controls, and the DP and D associations with PJCA were independent of each other. However, the combined presence of DPw2 and Dw5 and/or Dw8 gave a significantly higher risk of PJCA than each antigen alone indicating interaction of DP and DR gene products. PJCA is the first disease definitely found to be associated with a DP antigen. |
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