Pilot toxicokinetic study and absolute oral bioavailability of the Fusarium mycotoxin enniatin B1 in pigs |
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| Affiliation: | 1. Section of Experimental Biomedicine, Norwegian School of Veterinary Science, Oslo, Norway;2. Mekelle University College of Veterinary Medicine, Mekelle, Ethiopia;3. Sokoine University of Agriculture, Morogoro, Tanzania;4. Institute for Global Food Security, School of Biological Sciences, Queen’s University Belfast, Northern Ireland, UK;5. Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, P.O. Box 5003, N-1432 Ås, Norway;1. Department of Veterinary Medicine (DIMEVET), Università degli Studi di Milano, Via Celoria 10, 20133, Milan, Italy;2. Department of Animal and Food Sciences, Oklahoma State University, Stillwater, OK, 74078, USA;1. Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium;2. Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium;1. Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés s/n, 4610, Burjassot, Spain;2. School of Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil |
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| Abstract: | The aim of present study was to reveal the toxicokinetic properties and absolute oral bioavailability of enniatin B1 in pigs. Five pigs were administered this Fusarium mycotoxin per os and intravenously in a two-way cross-over design. The toxicokinetic profile fitted a two-compartmental model. Enniatin B1 is rapidly absorbed after oral administration (T1/2a = 0.15 h, Tmax = 0.24 h) and rapidly distributed and eliminated as well (T1/2elα = 0.15 h; T1/2elβ = 1.57 h). The absolute oral bioavailability is high (90.9%), indicating a clear systemic exposure. After intravenous administration, the mycotoxin is distributed and eliminated rapidly (T1/2elα = 0.15 h; T1/2elβ = 1.13 h), in accordance with oral administration. |
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| Keywords: | Toxicokinetics Absolute oral bioavailability Mycotoxin Enniatin B1 Pig |
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