Evaluation of subchronic inhalation toxicity of methylcyclopentane in rats |
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| Affiliation: | 1. Jeonbuk Department of Non-human Primate, Korea Institute of Toxicology, Jeonbuk 580-185, Republic of Korea;2. Chemical Safety and Health Research Center, Occupational Safety and Health Research Institute, KOSHA, Daejeon 305-380, Republic of Korea;3. College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Republic of Korea;1. School of Public Health, University of California, Berkeley, CA, United States;2. Electric Power Research Institute, Palo Alto, CA, United States;1. Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA;2. Knowledge and Evaluation Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA;3. Mayo Graduate School, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA;4. Center for the Science of Healthcare Delivery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA;5. Division of Preventive, Occupational and Aerospace Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA;1. Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje University, Inje-ro, Gimhae-si, Gyeongsangnam-do, Korea;2. Department of Biomedical Laboratory Science, College of Medical Science, Konyang University, Gasuwon-dong, Seo-gu, Daejeon, Korea;3. Laboratory of Veterinary Physiology and Signaling, College of Veterinary Medicine, Kyungpook National University, Buk-gu, Daegu, Korea |
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| Abstract: | The aim of this study was to verify subchronic inhalation toxicity of methylcyclopentane (CAS No. 96-37-7) in Sprague-Dawley rats. Four groups of 10 rats of each gender were exposed to methylcyclopentane vapor by whole-body inhalation at concentrations of 0, 290, 1300, or 5870 ppm for 6 h per day, 5 days/week over a 13-week period. During the study period, clinical signs, mortality, body weight, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross pathology, organ weights, and histopathology were examined. Exposure-related clinical signs (salivation and rubbing) were observed in both genders of the 5870 ppm group. There was an increase in liver weight for both genders but the kidney weight was only higher in females than controls. However, no toxicologically significant changes were observed in body weight, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, necropsy findings, or histopathology in any of the treatment groups. Under the present experimental conditions, the target organs were determined to be kidney and liver in rats. The no-observed-adverse-effect concentration was considered to be 1300 ppm/6 h/day in rats. |
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| Keywords: | Methylcyclopentane Subchronic toxicity Inhalation Whole-body exposure Rats |
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