Hypolipidaemic effect of crude extract from Carpobrotus rossii (pigface) in healthy rats |
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| Affiliation: | 1. University of Tasmania, School of Pharmacy, Private Bag 26, Hobart, Tasmania 7005, Australia;2. University of Tasmania, School of Human and Life Sciences, Locked Bag 1320, Launceston, Tasmania 7250, Australia;3. University of Tasmania, Central Science Laboratory, Private Bag 74, Hobart, Tasmania 7005, Australia;1. School of Biological Sciences, The University of Queensland, Brisbane, Queensland, 4072, Australia;2. Department of Zoology, University of Otago, P.O. Box 56, Dunedin, 9054, New Zealand;3. Department of Agricultural Biotechnology, Faculty of Agriculture, ISUBU, Isparta, 32260, Turkey;4. Department of Agriculture and Fisheries, EcoSciences Precinct, GPO Box 267, Brisbane, Queensland, 4001, Australia;1. Center for Biomedical Mass Spectrometry, Boston University School of Medicine, 670 Albany Street, 5th fl, Boston, MA 02118, USA;2. Alan and Sandra Gerry Amyloid Research Laboratory, Boston University School of Medicine, 72 East Concord Street, K-504, Boston, MA 02118, USA;1. Department of Bioengineering, Rice University, Houston, Texas, USA;2. Division of Gastroenterology, The Mount Sinai Medical Center, New York, New York, USA;3. Department of Pathology, The Mount Sinai Medical Center, New York, New York, USA;4. Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA;5. Department of Neurosurgery, The University of Texas Medical School at Houston, Houston, Texas, USA;6. Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, USA;7. Division of Digestive Diseases, Yale-New Haven Hospital, New Haven, Connecticut, USA;8. Department of Pathology, Baylor College of Medicine, Houston, Texas, USA;1. Council of Scientific and Industrial Research (CSIR) – Institute of Genomics and Integrative Biology (IGIB), Mall Road, Delhi 110007, India;2. Institute of Molecular Medicine, 254 Okhla Industrial Estate Phase 3, New Delhi 110020, India;1. Laboratory of Biochemistry, Faculty of Medicine Sousse, 4002, Sousse;4. University of Sousse, Tunisia;2. Laboratory UR12ES05 ‘Nutrition, Fonctionnels Food & Vascular Health’, Faculty of Medicine Monastir, 5019 University of Monastir, Tunisia;3. Laboratory of Interfaces and Advanced Materials, Faculty of Sciences of Monastir, 5000 University of Monastir, Tunisie |
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| Abstract: | Carpobrotus rossii (CR) was used by the Aboriginal population and early European settlers both as a food and therapeutic agent. Based on the presence of flavonoids in CR and results from our previous in vitro investigations, this study aimed to determine whether consumption of CR crude leaf extract: (a) affected lipoprotein profile, resting glucose, systolic blood pressure and vascular function, and (b) produced toxic effects (haematological measures, organ weight) in healthy rats. Male Hooded-Wistar rats (∼230 g) were supplemented for 4 weeks with CR extract in their drinking water (35 mg/kg body weight daily). CR extract produced a significant decrease (18%, p = 0.033) in atherogenic lipoproteins (but not high density lipoprotein). CR supplemented animals showed no signs of haematological toxicity and body and organ weight, daily fluid and food consumption and in vitro vascular responsiveness were similar for both groups. CR also increased (40%, p = 0.049) the renal concentration of 3-hydroxy-3-methylglutaric acid (HMG), consistent with HMG-containing CR flavonoids being bioavailable, and therefore possessing the potential to interfere with cholesterol synthesis pathways. CR extract appears to be safe to ingest and may reduce cardiovascular risk. |
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| Keywords: | Cardiovascular Lipid Toxicology Polyphenolic Flavonoid |
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