Sister chromatid exchange, (SCE), High-Frequency Cells (HFCs) and SCE distribution patterns in peripheral blood lymphocytes of Spanish adult smokers compared to non-smokers |
| |
| Institution: | 1. Department de Medicina Preventiva i Salut Pública, Facultat de Farmàcia, Universitat de Valencia, Burjassot, Spain;2. Unidad de Bioestadística IIS La Fe, Instituto de Investigación Sanitaria La Fe, Valencia, Spain;3. Servicio de Protección Radiológica, Hospital Universitario Politécnico La Fe, Valencia, Spain;4. Servicio de Salud Laboral, Dirección General de Salud Pública, Consellería de Sanitat, Generalitat Valenciana, Spain;5. Institut de Radioprotection et SûretéNucléaire (IRSN), PRP-HOM, SRBE, LDB.BP017, 92262 Fontenay-aux-Roses, France;6. Departamento de Ingeniería Química y Nuclear, Univeristat Politécnica de Valencia, Camino de Vera s/n, Spain;7. Servicio de Hematología, Hospital Universitario y Politécnico La Fe, Valencia, Spain;1. Department of General Surgery, Colorectal Unit, La Fe University and Polytechnic Hospital, University of Valencia, Valencia, Spain;2. Department of Gastroenterology, Inflammatory Bowel Disease Unit, La Fe University and Polytechnic Hospital, Valencia, Spain;3. Centro de investigación biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain;4. La Fe Institute for Health Research, Biostatistics Unit, Valencia, Spain;1. Department of Medicine, New York Medical College, Valhalla, New York;2. Division of Cardiology, New York Medical College, Valhalla, New York;3. Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama;4. Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California;1. Unidad de Cirugía Digestiva, Hospital Universitario y Politécnico La Fe, Universidad de Valencia, Valencia, España;2. Unidad de Bioestadística, Instituto de Investigación Sanitaria La Fe, Valencia, España;3. Servicio de Cirugía General, Hospital Universitario de Getafe, Madrid, España;4. Hospital General Universitario de Alicante, Alicante, España;5. Hospital Universitari Arnau de Vilanova, Lleida, España;6. Hospital de Cruces, Bilbao, España;7. Hospital Arquitecto Marcide, Ferrol, España;8. Hospital Arnau de Vilanova, Valencia, España;1. Division of Cardiology, “Maggiore della Carità” Hospital, Eastern Piedmont University, Novara, Italy;2. Division of Cardiology Careggi Hospital, Florence, Italy;3. Nuclear Medicine Unity, University of Florence, Florence, Italy |
| |
| Abstract: | According to the International Agency for Research on Cancer, smoking tobacco is a major cause of cancer in humans. It causes about half of all male cancer deaths and an ever increasing number of cancer deaths in females. The aim of this study was to establish whether cigarette smoking increases sister chromatid exchanges (SCEs) in peripheral blood lymphocytes in two Spanish population groups; light and heavy smokers. The mean number of High-Frequency Cells (HFCs) was determined and, the SCE distribution pattern among the chromosomes was analysed represented by a ratio described below. A local sample of 101 adult smokers (n = 48) and non-smokers (n = 53), aged from 18 to 49 years, was studied using SCE levels in peripheral lymphocytes. Heavy smoking (?10 cigarettes per day) increased significantly the SCE frequency and the HFC parameters. Neither age nor sex significantly influenced the frequencies in the groups studied. |
| |
| Keywords: | Tobacco Cytogenetic assessment Biomarker SCEs |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
