雌激素受体与数种血管形成因子在血管瘤和血管畸形中的表达

目的:探讨雌激素受体与数种血管形成因子在血管瘤和血管畸形病理发生中的作用。方法:对35例手术切除的血管瘤及血管畸形标本及5例正常皮肤标本,采用免疫组织化学方法检测雌激素受体以及血管形成有关的血管内皮细胞生长因子、基质金属蛋白酶和组织蛋白酶D。结果:在血管瘤增生期,ER、VEGF、MMP-2及组织蛋白酶D均有较高表达;在血管瘤退化期,仅ER和组织蛋白酶D有较高表达;在血管畸形和正常皮肤对照中,ER、VEGF和MMP-2表达极弱,组织蛋白酶D有少许表达。结论:雌激素与多种血管形成因子可通过不同途径对血管瘤的病理发生过程发挥作用,对血管畸形则无作用。

The Expression of Estrogen Receptor and Several Angiogenesis Factors in Hemangioma and Vascular Malformation

Objective: To find out the effect of estrogen receptor and several angiogenesis factors on the pathogenesis of hemangioma and vascular malformation. Methods:35 fresh operative specimens were collected. The specimens were divided into two groups: hemangioma and vascular malformation. 5 specimens of normal skin were also collected. Estrogen receptor, vascular endothelial growth factor, matrix metal proteinasa - 2, and cathepsin D were detected by immunohistochemical method. Results:High expressions of ER, VEGF,MMP- 2,and cathepsin D were present in proliferating hemangioma. But in the involuting hemangioma, only ER and cathepsin D had high expressions. ER.VEGF,and MMP-2 had very weak expressions in vascular malformation, as well as the control. Cathepsin D had low expressions in vascular malformation and the control. Conclusion: Estrogen and several angiogenesis factors have effects on the pathogenesis of hemangioma. They may have no effect on vascular malformation.