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A cross-sectional,mono-centric pilot study of insulin resistance in enzyme replacement therapy patients with Gaucher type I without overweight |
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| Authors: | Sema Kalkan Ucar Mahmut Coker Mehmet Argin Sezin Akman Sinan Kara Damla Goksen Simsek Sukran Darcan |
| Affiliation: | 1. Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran;2. Department of New Science and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;3. Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;4. Division of Applied Medicine, Medical School, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK;5. Department of Biochemistry, International Campus of Shahid Sadoughi University of Medical Sciences, Yazd, Iran;6. Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK |
| Abstract: | Insulin resistance have been demonstrated in untreated patients with Gaucher type I disease. It was implied in overweight enzyme replacement therapy (ERT) treated patients with Gaucher type I disease. In present study we investigate whether insulin resistance is presented in fourteen ERT treated patients with Gaucher type I disease and without overweight in comparison to normal subjects. This work illustrates the presence of insulin resistance in non-overweight ERT treated patients with Gaucher type I disease. |
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