Contribution of Fat-Free Mass and Fat Mass to Bone Mineral Density Among Reproductive-Aged Women of White,Black, and Hispanic Race/Ethnicity |
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| Authors: | Abbey B. Berenson Carmen Radecki Breitkopf Jennifer L. Newman Mahbubur Rahman |
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| Affiliation: | 1. Department of Chronic Disease Management, Philips Research, Eindhoven, the Netherlands;2. Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands;3. ICREC Research Program, Fundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Badalona, Spain;4. Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain;1. Children''s Hospital Oakland Research Institute, Oakland, CA, USA;2. Department of Hematology, UCSF Benioff Children''s Hospital, Oakland, CA, USA;1. Department of General Surgery, University of California, Irvine, Orange, California;2. Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio;3. Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio |
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| Abstract: | The objective of the study was to evaluate the contribution of fat-free mass (FFM) and fat mass (FM) to bone mineral density (BMD) and bone mineral apparent density (BMAD) among reproductive-aged women. Dual-energy X-ray absorptiometry scans were performed on 708 healthy black, white, and Hispanic women, 16–33 yr of age. The independent effect of FFM and FM on BMD and BMAD and the interaction of body composition measurements with race/ethnicity and age, were evaluated. FFM correlated more strongly than FM with BMD at the lumbar spine (r = 0.52 vs r = 0.39, p < 0.01) and the femoral neck (r = 0.54 vs r = 0.41, p < 0.01). There was a significant positive association between bone density measures [ln(BMD) and ln(BMAD)] and both ln(FFM) and ln(FM). The association of FFM with spinal BMD was stronger in 16–24-yr-old women than in 25–33-yr-old women (p < 0.006). The effect of FFM on femoral neck BMD was greater in blacks (p < 0.043) than Hispanics, whereas the effect of FM on spinal BMD was less (p < 0.047). Both FM and FFM are important contributors to bone density although the balance of importance is slightly different between BMD and BMAD. |
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