Mode of action of anti-lymphocyte globulin: I. The distribution of rabbit anti-lymphocyte globulin injected into rats and mice

The distribution of rabbit anti-lymphocyte globulin (IgG) following injection into rats and mice has been studied by immunofluorescence and ¹³¹I labelling, and the tissues from treated animals have been examined by electron-microscopy. The results suggest that the anti-lymphocyte globulin reacts primarily with circulating lymphocytes, and that it penetrates the thymus, spleen and lymph nodes to a limited extent. These findings may explain the selective immuno-suppressive action of anti-lymphocyte globulin.