Glucocorticoid inhibition of fibroblast contraction of collagen gels |
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| Authors: | P E Van Story-Lewis H C Tenenbaum |
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| Affiliation: | 1. Institute of Pharmacy, Freie Universität Berlin, Königin-Luise-Str. 2 + 4, Berlin 14195, Germany,;2. Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Christian-Albrechts-Universität zu Kiel, Kiel 24118, Germany;3. School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, 92 Weijin Lu, Nankai District, Tianjin 300072, China;4. Laboratorio Antidoping FMSI, Largo Giulio Onesti 1, Rome 00197, Italy,;5. REDs - Research and Expertise on Antidoping sciences, ISSUL – Institute des sciences du sport, Université de Lausanne, Synathlon 3224 – Quartier Centre, Lausanne 1015, Switzerland |
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| Abstract: | When skin fibroblasts are grown in culture on collagen gels, the collagen gels contract. We have studied the effects of various steroids on the contraction process. Cortisol, beta-estradiol and dexamethasone inhibited fibroblast-mediated gel contraction at low (10(-8) to 10(-9) M) concentrations whereas dihydrotestosterone was without effect. These effects were time and concentration dependent and could be reversed if the steroids were removed. This system may be useful for assaying the activities of various steroids in terms of their activities and modulating effects on connective tissue. |
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