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Expression of pleiotrophin in the prostate is androgen regulated and it functions as an autocrine regulator of mesenchyme and cancer associated fibroblasts and as a paracrine regulator of epithelia |
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| Authors: | Brigid Orr Griet Vanpoucke O. Cathal Grace Lee Smith Richard A. Anderson Antony C.P. Riddick Omar E. Franco Simon W. Hayward Axel A. Thomson |
| Affiliation: | 1. MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, Edinburgh, UK;2. Centre for Reproductive Biology, Reproductive and Developmental Sciences Section, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, UK;3. Urology Department, Western General Hospital, Edinburgh, UK;4. Departments of Urologic Surgery and Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee |
| Abstract: | |
| Keywords: | prostate prostate development mesenchyme stroma stromal/epithelial interactions cancer associated fibroblasts pleiotrophin androgens |